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Embark on an Unforgettable Adventure: Your 7-Day Panama Itinerary from Casco Viejo to Bocas del Toro and Panama City!

Welcome to the vibrant destination of Panama, where history, nature, and culture intertwine to offer you an unforgettable 7-day exploration like no other. In this itinerary, you will immerse yourself in the charming streets of Casco Viejo, relax on the pristine beaches of Bocas del Toro, and experience the modernity of downtown Panama City.


Sign of Panama
Amador Causeway

Day 1-2: Historic Charm of Casco Viejo


Start your journey by stepping back in time with a 2-night stay in Casco Viejo, the historical heart of Panama City. This UNESCO World Heritage site is a mesmerizing blend of colonial architecture, colorful buildings, and quaint cobblestone streets.


  • Accommodation: Check into a unique, boutique hotel, such Hotel La Compañia, Sofitel Legend Casco Viejo, or Amarla Boutique Hotel Casco Viejo, that exudes old-world charm, offering a glimpse into the rich history of Panama.

  • Dining: Villa Ana offers a unique blend of art and culture. Caleta Restaurant is a culinary gem that blends the artistry of fine dining with the vibrant flavors of Panamanian cuisine. CasaCasco features three distinct restaurants: Kobore, Marula, and Asian, each offering a unique culinary experience. From Japanese fusion to Mediterranean cuisine, the restaurant caters to a variety of tastes.

  • Must-Visit: Explore Plaza de la Independencia, visit Panama Canal Museum, explore the Rainforest Discovery Center, and stroll along the picturesque waterfront for stunning views of the skyline.


hotel room display with tv and closet
Hotel La Compania
hotel pool with pouring water
Sofitel Legend Casco Viejo
Amarla Boutique Hotel Casco Viejo

Day 3-5: Tropical Paradise in Bocas del Toro


Next, indulge in a 3-night getaway in the enchanting archipelago of Bocas del Toro, known for its crystal-clear waters, lush rainforests, and laid-back vibe. Embrace the island life and let the pristine beauty of nature captivate your soul.


  • Travel: Hop on a short flight with Air Panama or take a scenic bus journey to reach Bocas del Toro from Panama City.

  • Accommodation: Choose a beachfront bungalow or an overwater villa at Nayara Bocas del Toro or La Coralina Island House, offering direct access to the turquoise waters of the Caribbean Sea.

  • Must-Do: Snorkel at Starfish Beach, surf the waves at Red Frog Beach, and cruise through the mangroves in search of wildlife.


Wow, you absolutely have to see the breathtaking views from Nayara Bocas del Toro below! Get ready to be amazed!


Day 6-7: Urban Excitement in Downtown Panama City


Wrap up your adventure with a 2-night stay in the bustling metropolis of Panama City, where skyscrapers tower over the historic sites, creating a unique juxtaposition of the old and the new.


  • Travel: Take a short flight with Air Panama  or a scenic boat ride back to Panama City from Bocas del Toro.

  • Accommodation: Opt for a luxurious hotel with panoramic city views at the Bristol Panama Hotel, allowing you to witness the vibrant energy of Panama City's downtown.

  • Dining: CasaCasco features three distinct restaurants: Kobore, Marula, and Asian, each offering a unique culinary experience. From Japanese fusion to Mediterranean cuisine, the restaurant caters to a variety of tastes.

  • Must-See: Visit the iconic Panama Canal, explore Amador Causeway, shop at Albrook Mall, and dine at rooftop restaurants overlooking the city skyline.


bathroom view with sink and shower
bedroom view
panama hats on the ceiling
piano in front of wall art

As your 7-day journey comes to an end, reflect on the diverse experiences Panama has offered. From the historic charm of Casco Viejo to the tropical allure of Bocas del Toro and the urban excitement of downtown Panama City, each moment is a piece of a memorable puzzle that forms your Panama adventure.


Get ready to embark on an odyssey filled with culture, nature, and unforgettable moments. Panama awaits you with open arms, ready to unveil its wonders one day at a time. Start your journey today and let Panama captivate your heart like never before!


Embark on a memorable Panamanian adventure exploring lush rainforests, pristine beaches, and vibrant cities. Book through a travel advisor HERE for a seamless experience tailored to your preferences. Don't miss the chance to visit the Panama Canal, immerse in indigenous cultures, and savor local cuisine. Create lasting memories – book your escape now!


Pack your bags, embrace the unknown, and set off on this 7-day Panama itinerary that promises to leave you spellbound at every turn!

Urban Excitement

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Rissa What's Next is a travel and lifestyle blog where I share my journey and talk about a variety of topics from travel to beauty to personal development to health and wellness.

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